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A novel multifunctional poly amidoamine dendrimeric

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Poly (amidoamine) (PAMAM) dendrimer mediated delivery of .

Poly (amidoamine) (PAMAM) dendrimers are well-defined, highly branched macromolecules with numerous active amine groups on the surface. Because of their unique properties, PAMAM dendrimers have steadily grown in popularity in drug delivery, gene therapy, medical imaging and diagnostic application.

Dendrimer - Wikiped

Poly(amidoamine), or PAMAM, is perhaps the most well known dendrimer. The core of PAMAM is a diamine (commonly ethylenediamine), which is reacted with methyl acrylate, and then another ethylenediamine to make the generation-0 (G-0) PAMAM. Successive reactions create higher generations, which tend to have different properties.

Poly(amidoamine) Dendrimer-Based Multifunctional .

Poly(amidoamine) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy István J. Majoros * , Thommey P. Thomas , Chandan B. Mehta , and James R. Baker Center for Biologic Nanotechnology, University of Michigan, 200 Zina Pitcher Place, 4027 Kresge II, Ann Arbor, Michigan 48109-0533

Methoxy PEG Succinimidyl Carboxymethyl - JenK

Description. Methoxy PEG Succinimidyl Carboxymethyl Ester for amine PEGylation, with superior quality specification of ≥95% Substitution.. JenKem Technology’s Methoxy PEG Succinimidyl Carboxymethyl Ester (Methoxy PEG NHS or Methoxy PEG SCM) is a high quality amine reactive PEG product with a stable non-degradable linker between the PEG polymeric chain and the NHS ester.

A magnetic multifunctional dendrimeric coating on a steel .

A magnetic multifunctional dendrimeric coating on a steel fiber for solid phase microextraction of chlorophenols. ... (2012) Magnetic nanoparticles coated by acidic functionalized poly (amidoamine) dendrimer: effective acidic organocatalyst. ... Electrospun modified silica-polyamide nanocomposite as a novel fiber coating.

Acid- and Salt-Triggered Multifunctional Poly(propylene .

A novel dendrimeric compound is designed with the objective of simultaneously addressing issues commonly encountered in drug delivery, i.e., stability in biological ...

Acid- and Salt-Triggered Multifunctional Poly(propylene .

Acid- and Salt-Triggered Multifunctional Poly(propylene imine) Dendrimer as a Prospective Drug Delivery System Constantinos M. Paleos * , Dimitris Tsiourvas , Zili Sideratou , and Leto Tziveleka Institute of Physical Chemistry, NCSR “Demokritos”, 15310 Aghia Paraskevi, Attiki, Greece

Dendrimer - Wikiped

Poly(amidoamine), or PAMAM, is perhaps the most well known dendrimer. The core of PAMAM is a diamine (commonly ethylenediamine), which is reacted with methyl acrylate, and then another ethylenediamine to make the generation-0 (G-0) PAMAM. Successive reactions create higher generations, which tend to have different properties.

Invading target cells: multifunctional polymer conjugates as .

Invading target cells: multifunctional polymer conjugates as ...

陈泽铭 – Postdoctoral Researcher – 耶鲁大学 | Linked

Sehen Sie sich das Profil von 陈泽铭 auf LinkedIn an, dem weltweit größten beruflichen Netzwerk. 2 Jobs sind im Profil von 陈泽铭 aufgelistet. Sehen Sie sich auf LinkedIn das ...

Targeted Dendrimeric Anticancer Prodrug: A Methotrexate .

A targeted dendrimeric anticancer prodrug, a conjugate of Generation 5 (G5) polyamidoamine (PAMAM) dendrimer, folic acid (FA), and methotrexate (MTX), has been successfully synthesized by using a novel “one pot” approach which is simple, reproducible and feasible for large-scale synthesis.

(S)-10-Hydroxycamptothecin | CAS:19685-09-7 | inhibitor of .

IC50: 0.31 μM. 10-Hydroxycamptothecin is a dose-dependent growth inhibitor of human microvascular endothelial cells (HMEC), and significantly inhibits the migration of HMEC with IC50 of 0.63 μM, resulting in a dose-dependent inhibition of tube formation with IC50 of 0.96 μM [1,2].

Poly(propylene imine) Dendrimers: Large‐Scale Synthesis by .

Eva-Maria Christ, Jana Herzberger, Mirko Montigny, Wolfgang Tremel and Holger Frey, Poly(THF- co -cyano ethylene oxide): Cyano Ethylene Oxide (CEO) Copolymerization with THF Leading to Multifunctional and Water-Soluble PolyTHF Polyelectrolytes , Macromolecules, 10.1021/acs.macromol.6b00113, 49, 10, (3681-3695), (2016).

Analysis of poly(amidoamine)‐succinamic acid dendrimers by .

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

International Journal of Pharmaceutics - download.xuebalib.c

leakage during circulation, we prepared a novel multifunctional dendrimeric carrier by integrating long hydrophobicC 12 alkylchains,poly(ethyleneglycol)chainsandc(RGDfK)ligandspresentedonthesurface. This dendrimer was able to tightly encapsulate the hydrophobic anticancer drug 10-hydroxycampto-

A novel multifunctional poly(amidoamine) dendrimeric .

The fourth generation PAMAM dendrimer with partial conjugation of long hydrophobic C 12 alkyl chains (G4-25%C 12 PAMAM, approximately 16 chains per dendrimer) on the surface was used as the starting material for modification with fluorescent dyes and mPEG 5000 chains. FITC (rhodamine was used instead in the microscopy experiments due to its better photostability) was used to fluorescently ...

International Journal of Pharmaceutics - download.xuebalib.c

leakage during circulation, we prepared a novel multifunctional dendrimeric carrier by integrating long hydrophobicC 12 alkylchains,poly(ethyleneglycol)chainsandc(RGDfK)ligandspresentedonthesurface. This dendrimer was able to tightly encapsulate the hydrophobic anticancer drug 10-hydroxycampto-

Poly(amidoamine) Dendrimer‐Based Multifunctional .

Poly(amidoamine) (PAMAM) dendrimers carrying different amounts of surface amino groups were synthesized and tested for their effects on cellular cytotoxicity, lysosomal pH, and mitochondria ...

Yuxi Li - Semantic Schol

With the aim of developing an efficient targeted delivery system for cancer therapy that overcomes drug leakage during circulation, we prepared a novel multifunctional dendrimeric carrier by … (More)

Poly(amidoamine) Dendrimer‐Based Multifunctional .

Request PDF on ResearchGate | On Feb 19, 2007, Thommey P. Thomas and others published Poly(amidoamine) Dendrimer‐Based Multifunctional Nanoparticles